Risdiplam
Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1].
Product Specifications
CAS Number
[1825352-65-5]
Product Name Alternative
RG7916; RO7034067
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Risdiplam.html
Purity
99.64
Solubility
DMSO : 1.96 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C) |H2O : < 0.1 mg/mL
Smiles
O=C(C=C(C(C=C1C)=NN2C1=NC(C)=C2)N=C3C=C4)N3C=C4N(CCN5)CC65CC6
Molecular Formula
C22H23N7O
Molecular Weight
401.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Poirier A, et al. Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs. Pharmacol Res Perspect. 2018 Nov 29;6 (6) :e00447.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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