Tenidap

Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].

Product Specifications

CAS Number

[120210-48-2]

Product Name Alternative

CP-66248

UNSPSC

12352005

Hazard Statement

H302

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tenidap.html

Concentration

10mM

Purity

99.32

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O/C(C1=CC=CS1)=C2C3=C(C=CC(Cl)=C3)N(C(N)=O)C/2=O

Molecular Formula

C14H9ClN2O3S

Molecular Weight

320.75

Precautions

H302

References & Citations

[1]Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1094-101.|[2]Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38 (10) :1447-56.|[3]Julio C Chávez, et al. Participation of the Cl-/HCO (3) - exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan 19;86 (1) :1-14.