DMTMM

DMTMM (4- (4,6-dimethoxy-1,3,5-triazine-2-yl) -4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[3945-69-5]

Product Name Alternative

4- (4,6-Dimethoxy-1,3,5-triazin-2-yl) -4-methylmorpholinium chloride

UNSPSC

12352200

Hazard Statement

H302, H314

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dmtmm.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[N+]1(C2=NC(OC)=NC(OC)=N2)CCOCC1.[Cl-]

Molecular Formula

C10H17ClN4O3

Molecular Weight

276.72

Precautions

H302, H314

References & Citations

[1]Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.|[2]Plaster E M, et al. DMTMM-mediated synthesis of norbornene-modified hyaluronic acid polymers to probe cell-hydrogel interactions. Carbohydrate Polymer Technologies and Applications, 2023, 6: 100360.|[3]Simpson FC, et al. Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs. Commun Biol. 2021 May 21;4 (1) :608. |[4]Labre F, et al. DMTMM-mediated amidation of alginate oligosaccharides aimed at modulating their interaction with proteins. Carbohydr Polym. 2018 Mar 15;184:427-434. |[5]Magalhães MV, et al. In situ crosslinkable multi-functional and cell-responsive alginate 3D matrix via thiol-maleimide click chemistry. Carbohydr Polym. 2024 Aug 1;337:122144. |[6]Jo G, et al. Tumor Targeting with Methotrexate-Conjugated Zwitterionic Near-Infrared Fluorophore for Precise Photothermal Therapy. Int J Mol Sci. 2022 Nov 16;23 (22) :14127. |[7]Morieux P, et al. Synthesis and anticonvulsant activities of N-benzyl (2R) -2-acetamido-3-oxysubstituted propionamide derivatives. Bioorg Med Chem. 2008 Oct 1;16 (19) :8968-75.|[8]Hyun H, et al. Engineered beta-cyclodextrin-based carrier for targeted doxorubicin delivery in breast cancer therapy in vivo. Journal of Industrial and Engineering Chemistry, 2019, 70: 145-151.