Zoledronic Acid

Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1].

Product Specifications

CAS Number

[118072-93-8]

Product Name Alternative

Zoledronate; CGP 42446; CGP42446A; ZOL 446

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zoledronic-acid.html

Purity

99.94

Solubility

H2O : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

Molecular Formula

C5H10N2O7P2

Molecular Weight

272.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059.|[2]Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20 (6) : 1467.|[3]Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44 (2) :582-592.|[4]XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13 (1) : 613-622.|[5]Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15 (18) :5829-39.|[6]Shea GKH, et al. Oral Zoledronic acid bisphosphonate for the treatment of chronic low back pain with associated Modic changes: A pilot randomized controlled trial. J Orthop Res. 2022 Feb 23.