L2H2-6OTD intermediate-1
L2H2-6OTD intermediate-1 is an intermediate for the synthesis of L2H2-6OTD (HY-148200) and can be used for ADC preparation. L2H2-6OTD, a telomestatin analog with telomerase inhibitory activity (IC50: 15 nM) [1].
Product Specifications
CAS Number
[912656-47-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l2h2-6otd-intermediate-1.html
Purity
98.40
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=NC(C3=NC(C(OC)=O)=CO3)=C(O2)C)N=C(O1)[C@H](CSC(C)(C)C)NC(OC(C)(C)C)=O
Molecular Formula
C24H32N4O7S
Molecular Weight
520.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Doi Takayuki, et al. Total Synthesis of (R) -Telomestatin. Organic Letters (2006), 8 (18), 4165-4167.|[2]Kazuaki Shibata, et al. Synthesis of Heptaoxazole Macrocyclic Analogues of Telomestatin. Chem. Soc. Jpn. Vol. 86, No. 12, 14531465
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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