Yatein

Yatein is a lignan isolated from A. chilensis, with antiproliferative activity[1]. Yatein suppresses herpes simplex virus type 1 (HSV-1) replication by interruption the immediate-early gene expression[2].

Product Specifications

CAS Number

[40456-50-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; HSV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/yatein.html

Purity

99.76

Solubility

10 mM in DMSO

Smiles

O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(OC)C(OC)=C4

Molecular Formula

C22H24O7

Molecular Weight

400.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53 (3) :378-85.|[2]Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70 (3) :112-20.|[3]Shang-Tse Ho, et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel) . 2019 Sep; 11 (9) : 1384.