N-Nitrosomorpholine

N-Nitrosomorpholine is a photosensitive nitrosamine that is carcinogenic and can be used to construct animal cancer models[1].

Product Specifications

CAS Number

[59-89-2]

UNSPSC

12352005

Hazard Statement

H301, H351

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-nitrosomorpholine.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=NN1CCOCC1

Molecular Formula

C4H8N2O2

Molecular Weight

116.12

Precautions

H301, H351

References & Citations

[1]K D Brunnemann, et al. N-Nitrosomorpholine and Other Volatile N-nitrosamines in Snuff Tobacco. Carcinogenesis. 1982;3 (6) :693-6.|[2]Kobusch AB, et al. Tumor-promoting activity and cytotoxicity of 3,4,3',4'-tetrachlorobiphenyl on N-nitrosomorpholine-induced murine liver foci. J Cancer Res Clin Oncol. 1989;115 (3) :247-52.|[3]Enzmann H, et al. Elevation of glucose-6-phosphate in early stages of hepatocarcinogenesis induced in rats by N-nitrosomorpholine. Horm Metab Res. 1988 Feb;20 (2) :128-9.|[4]Weber E, et al. Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis. 1994 Jun;15 (6) :1235-42.