Isecarosmab

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].

Product Specifications

CAS Number

[2254082-79-4]

Product Name Alternative

M-6495

UNSPSC

12352203

Target

ADAMTS

Type

Inhibitory Antibodies

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isecarosmab.html

Purity

96.95

Solubility

10 mM in DMSO

Smiles

[Isecarosmab]

Molecular Weight

(28.89 kDa)

References & Citations

[1]Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21 (17) :5992. |[2]Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28 (5) :658-668. |[3]C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495) . 2018. 26 (1), S299-S300.