L-Threonolactone
L-Threonolactone ((3R,4S) -3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[21730-93-8]
Product Name Alternative
(3R,4S) -3,4-Dihydroxyoxolan-2-one
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-threonolactone.html
Purity
98.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O[C@@H](CO1)[C@@H](O)C1=O
Molecular Formula
C4H6O4
Molecular Weight
118.09
Precautions
H302, H315, H319
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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