5-Hydroxytryptophol

5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse[1][2].

Product Specifications

CAS Number

[154-02-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-_2-Hydroxyethyl_-1H-indol-5-ol.html

Purity

99.13

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(NC=C2CCO)C=C1

Molecular Formula

C10H11NO2

Molecular Weight

177.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck O, et al. 5-hydroxytryptophol as a marker for recent alcohol intake. Addiction. 2003 Dec;98 Suppl 2:63-72.|[2]Eccleston D, et al. The formation of 5-hydroxytryptophol in brain in vitro. Br J Pharmacol Chemother. 1966 Dec;28 (3) :367-77.