PPI-GIT1/β-Pix interaction-IN-1
Product Specifications
UNSPSC Description
PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ppi-git1-β-pix-interaction-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1[C@@H](C(OCC)=O)[C@]2(C(N(C)C3=C2C=CC=C3)=O)[C@H]/4C1)C4=C\C5=COC=C5
Molecular Weight
391.42
References & Citations
[1]Gu J, et, al. Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 2022 Nov 23;13(1):7176.|[2]Gu J, et, al. Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 2022 Nov 23;13(1):7176.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-152095/PPI-GIT1-β-Pix-interaction-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-152095/PPI-GIT1-β-Pix-interaction-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2070916-70-8
Available Sizes
Curated Selection
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