Peimine

Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[23496-41-5]

Product Name Alternative

Verticine; Dihydroisoimperialine

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Apoptosis; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Peimine.html

Purity

99.9

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

[H][C@]12[C@]3([H])C[C@H](O)[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])C[C@]([H])1[C@]5([H])CN6C[C@@H](C)CC[C@]([H])6[C@@](C)(O)[C@]([H])5CC2

Molecular Formula

C27H45NO3

Molecular Weight

431.65

Precautions

H302+H312+H332

References & Citations

[1]Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35 (5) :567-72.|[2]Chen K, Lv ZT, Zhou CH, et al. Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med. 2019;43 (5) :2241-2251. |[3]Tan H, et al. Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+ /CaMKII/JNK pathway. J Cell Biochem. 2020 Jan;121 (1) :81-92. |[4]Liu C, et al. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation. J Ethnopharmacol. 2022 Sep 15;295:115343. |[5]Chen LH, et al. Sex dependent pharmacokinetics, tissue distribution and excretion of peimine and peiminine in rats assessed by liquid chromatography-tandem mass spectrometry. J Ethnopharmacol. 2013 Jan 9;145 (1) :77-84. |[6]Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35 (5) :567-72. |[7]Xu J, et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 2016 Jun;111:1-6.