TRPV4-IN-5
Product Specifications
UNSPSC Description
TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC50 = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice[1].
Target Antigen
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/trpv4-in-5.html
Smiles
O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=C(Cl)C=C(Cl)C=C3Cl
Molecular Weight
490.83
References & Citations
[1]Wang M, et al. Exploration and structure-activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury. Bioorg Chem. 2024 Jun;147:107396.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162765/TRPV4-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162765/
Clinical Information
No Development Reported
CAS Number
3046390-54-6
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