Pendimethalin

Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells[1][2][3][4].

Product Specifications

CAS Number

[40487-42-1]

UNSPSC

12352005

Hazard Statement

H302, H317, H400, H410

Target

Apoptosis; Bcl-2 Family; Caspase; SOD

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pendimethalin.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=[N+](C1=C(NC(CC)CC)C([N+]([O-])=O)=C(C)C(C)=C1)[O-]

Molecular Formula

C13H19N3O4

Molecular Weight

281.31

Precautions

H302, H317, H400, H410

References & Citations

[1]Martin Kočárek, et al. Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil. J Hazard Mater. 2018 Jul 15;354:266-274.|[2]Lee HS, et al. Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food Chem Toxicol. 2022 Oct;168:113370.|[3]Ansari SM, et al. Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells. Histochem Cell Biol. 2018 Feb;149 (2) :127-141. |[4]Ahmad MI, et al. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Sci Rep. 2018 Nov 20;8 (1) :17139.