Questin

Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer[1][2][3][4][5].

Product Specifications

CAS Number

[3774-64-9]

UNSPSC

12352005

Target

Bacterial; Parasite; Phosphatase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/questin.html

Purity

97.75

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C=C(O)C=C2OC)C(C3=CC(C)=CC(O)=C13)=O

Molecular Formula

C16H12O5

Molecular Weight

284.26

References & Citations

[1]Lei Guo, et al. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi. 3 Biotech. 2017 Dec;7 (6) :383.|[2]Choi SG, et al. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat Prod Res. 2007 May 20;21 (6) :487-93.|[3]Gauthier T, et al. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One. 2012;7 (2) :e29906.|[4]Liu N, et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia. 2019 Jun;135:27-32.|[5]Chaudhary NK, et al. Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus. J Nat Prod. 2018 Jul 27;81 (7) :1517-1526.