Harmine (Standard)
Product Specifications
UNSPSC Description
Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Target Antigen
5-HT Receptor; DYRK
Type
Reference Standards
Related Pathways
GPCR/G Protein;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/harmine-standard.html
Smiles
CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
Molecular Weight
212.25
References & Citations
[1]Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.|[2]Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859.|[3]Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.|[4]Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0737AR/Harmine-Standard-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0737AR/
CAS Number
442-51-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
