MCP-2 (CCL8) (Animal Free)
The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-2 (CCL8) is an 8.9 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Product Specifications
Synonyms
CCL8; HC14; MCP2; MCP-2; SCYA8; SCYA10
NCBI Gene ID
6355
UniProt
P80075
Accession Number
NP_005614
Accession Number mRNA
NM_005623
Chromosomal Location
17q11.2
Reactivity
Human
Cross Reactivity
Hamster, Monkey, Mouse, Rat, Human
Sequence
QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to chemoattract monocytic leukemia THP-1 cells.
Length
76
Form
Lyophilized
Molecular Weight
8.9 kDa
Host or Source
E. coli
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