MCP-1
Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein-1 (MCP-1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. In the human genome, CCL2 and many other CC chemokines are located on chromosome 17 (17q11.2-q21.1) . The gene span is 1,927 bases and the CCL2 gene resides on the Watson (plus) strand. The CCL2 gene has three exons and two introns. The CCL2 [protein precursor]] contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino acids long. The CCL2 predicted weight is 11.025 kDa.
Product Specifications
Synonyms
CCL2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
NCBI Gene ID
6347
UniProt
P13500
Accession Number
NP_002973
Accession Number mRNA
NM_002982
Chromosomal Location
17q11.2-q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human MCP-1
Applications
ELISA, WB, IHC (P)
Purification Method
Protein A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
Host or Source
Mouse
Isotype
IgG2a, kappa
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