IL-10 receptor beta

IL-10 mediates its biological activities via binding to a heteromeric complex of two distinct type II cytokine receptor subunits, the ligand binding subunit IL-10 R alpha (IL-10 R1) and the signal-transducing accessory subunit IL-10 R beta (IL-10 R2) . IL-10 R alpha is specific for IL-10 and expressed by most hemopoietic cells. IL-10 R beta is a widely expressed shared subunit for IL-10, IL-22, IL-26 and the IFNl proteins IL-28A, IL-28B and IL-29.

Product Specifications

Synonyms

IL10RB; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2

NCBI Gene ID

3588

UniProt

Q08334

Accession Number

NP_000619.3

Accession Number mRNA

NM_000628.4

Chromosomal Location

21q22.1-q22.2; 21q22.11

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human IL-10 Rbeta EC domain

Clone

(#8R24)

Applications

WB, N

Purification Method

Protein A/G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.