Complement Factor D (Adipsin)

Complement Factor D, also known as adipsin, is a serine protease that catalyzes the initial proteolytic step in the alternative pathway of complement. It is an exceptionally specific protease and the only known protein substrate is factor B in complex with C3.3 Factor D protease activity is regulated by reversible conformational changes, which differs from the majority of serine proteases whose regulation involves either activation by processing of the zymogens or inactivation by binding of the inhibitors.

Product Specifications

Synonyms

CFD; DF; ADN; PFD; ADIPSIN

NCBI Gene ID

1675

UniProt

P00746

Accession Number

NP_001919.2

Accession Number mRNA

NM_001928.2

Chromosomal Location

19p13.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant Complement factor D

Clone

(#4M47)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.