Amphiregulin
Amphiregulin is an EGF-related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Murine Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.
Product Specifications
Synonyms
AR, AREG, Colorectum cell-derived growth factor (CRDGF)
NCBI Gene ID
11839
UniProt
P31955
Accession Number
NP_033834.1
Accession Number mRNA
NM_009704.4
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
SVRVEQVIKP KKNKTEGEKS TEKPKRKKKG GKNGKGRRNK KKKNPCTAKF QNFCIHGECR YIENLEVVTC NCHQDYFGER CGEKSMKTHS EDDKDLSK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses
Bioactivity
Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
Length
98
Form
Lyophilized
Molecular Weight
11.3 kDa
Host or Source
E. coli
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