Medroxyprogesterone acetate

Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

Product Specifications

CAS Number

[71-58-9]

Product Name Alternative

Medroxyprogesterone 17-acetate; Farlutin

UNSPSC

12352211

Hazard Statement

H351, H413

Target

Androgen Receptor; Endogenous Metabolite; Glucocorticoid Receptor; Progesterone Receptor

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Medroxyprogesterone-acetate.html

Purity

99.88

Solubility

DMSO : 10 mg/mL (ultrasonic) |Ethanol : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

CC(O[C@@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](C)C3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC2)C(C)=O)=O

Molecular Formula

C24H34O4

Molecular Weight

386.52

Precautions

H351, H413

References & Citations

[1]Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61 (1-2) :171-80.|[2]Simoncini T, et al. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004 Dec;145 (12) :5745-56. |[3]Smith D, et al. Pharmacokinetics and bioavailability of medroxyprogesterone acetate in the dog and the rat. Biopharm Drug Dispos. 1993 May;14 (4) :341-55. |[4]Bernardi F, et al. Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology. 2006;83 (5-6) :348-59.