Picamilon

Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227) -induced diabetes mellitus in rats[1][2][3].

Product Specifications

CAS Number

[34562-97-5]

Product Name Alternative

Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/picamilon.html

Concentration

10mM

Purity

99.37

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CCCNC(C1=CN=CC=C1)=O)=O

Molecular Formula

C10H12N2O3

Molecular Weight

208.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Mirzoian RS, et al. Vliianie pikamilona na krovosnabzhenie kory i mikrotsirkuliatsiiu v sisteme pial'nykh arteriol [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989 May;107 (5) :581-2. Russian. |[2]Denisenko, et al. Effects of Picamilon and Isopicamilon on the Formation of Picrotoxin-Induced Convulsive Activity in Rats. Neurophysiology 46, 284–287 (2014) .