PQCA

PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].

Product Specifications

CAS Number

[1144504-35-7]

Product Name Alternative

CA-074Me

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pqca.html

Purity

99.96

Solubility

1 M NaOH : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 10 mg/mL (ultrasonic; warming; adjust pH to 8 with 1 M NaOH; heat to 60°C) |Methanol : 50 mg/mL (ultrasonic; adjust pH to 11 with NaOH)

Smiles

O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O

Molecular Formula

C22H20N4O3

Molecular Weight

388.42

References & Citations

[1]Lange HS, et al. The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. J Pharmacol Exp Ther. 2015 Dec;355 (3) :442-50.|[2]Uslaner JM, et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl) . 2013 Jan;225 (1) :21-30.