Givinostat
Product Specifications
UNSPSC Description
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Givinostat.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3
Molecular Weight
421.49
References & Citations
[1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.|[2]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.|[3]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.Acta Pharmacol Sin. 2021 Apr 13.|Cell Prolif. 2021 May 24;e13072.|Commun Biol. 2021 Oct 29;4(1):1235.|J Am Chem Soc. 2024 Sep 27.|J Orthop Transl. 29 (2021) 106-112.|Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.|Patent. US20240252638A1.|SSRN. 2024 Mar 13.|Cell Death Dis. 2020 Sep 15;11(9):753.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14842/Givinostat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14842/Givinostat-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
497833-27-9
Available Sizes
Curated Selection
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