LY450108

LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4].

Product Specifications

CAS Number

[376594-67-1]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LY450108.html

Purity

99.51

Solubility

DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL

Smiles

FC1=CC(F)=CC(C(NC2=CC=C([C@@H](C)CNS(C(C)C)(=O)=O)C=C2)=O)=C1

Molecular Formula

C19H22F2N2O3S

Molecular Weight

396.45

References & Citations

[1]Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160 (2) :181-190.|[2]O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8 (5) :603-20.|[3]Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46 (4) :424-32.|[4]Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.