LY3154207

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM) [1].

Product Specifications

CAS Number

[1638667-79-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly3154207.html

Concentration

10mM

Purity

98.06

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](C)C2=C(C(CCC(C)(O)C)=CC=C2)C[C@@H]1CO)CC3=C(Cl)C=CC=C3Cl

Molecular Formula

C24H29Cl2NO3

Molecular Weight

450.40

Precautions

H302, H315, H319

References & Citations

[1]Hao J, Synthesis and Pharmacological Characterization of 2- (2,6-Dichlorophenyl) -1- ((1S,3R) -5- (3-hydroxy-3-methylbutyl) -3- (hydroxymethyl) -1-methyl-3,4-dihydroisoquinolin-2 (1H) -yl) ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor. J Med Chem. 2019 Oct 10;62 (19) :8711-8732.