AB25583
AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1].
Product Specifications
CAS Number
[2565637-94-5]
UNSPSC
12352211
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ab25583.html
Purity
99.85
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
Molecular Formula
C22H17ClN4O3S
Molecular Weight
452.91
References & Citations
[1]Ito F, et al. Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14;15 (1) :7003.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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