GNF179

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency (IC50 of 4.8 nM against the multidrug resistant strain W2) . GNF179 is orally active[1].

Product Specifications

CAS Number

[1261114-01-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gnf179.html

Purity

96.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(C)C2=NC(C3=CC=C(F)C=C3)=C(NC4=CC=C(Cl)C=C4)N2CCN1C(CN)=O

Molecular Formula

C22H23ClFN5O

Molecular Weight

427.90

Precautions

H302, H315, H319, H335

References & Citations

[1]Meister S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334 (6061) :1372-7.|[2]Ouologuem DT, et al. A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes. Antimicrob Agents Chemother. 2022 Nov 2:e0100122.