EMD 52297

EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor[1][2].

Product Specifications

CAS Number

[129049-51-0]

UNSPSC

12352005

Target

Renin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/emd-52297.html

Smiles

O=C(NC(CC1=CC=CC=C1)C(NC(CC2=CN=CN2)C(NC(C(CC(NC(C(CC)C)C(NCN3N=NC=N3)=O)=O)O)CC4CCCCC4)=O)=O)OC(C)(C)C

Molecular Formula

C39H59N11O7

Molecular Weight

793.96

References & Citations

[1]Miriam T Rademaker, et al. Hemodynamic, hormonal, and renal effects of (pro) renin receptor blockade in experimental heart failure. Circ Heart Fail. 2012 Sep 1;5 (5) :645-52.|[2]Jürgen Maibaum, et al. Renin inhibitors as novel treatments for cardiovascular disease. Expert Opinion on Therapeutic Patents. Volume 13, 2003 - Issue 5.