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PPM1H Antibody

Human Anti-Human PPM1H Monoclonal IgG1

Product Specifications

Background

PPM1H is an independent prognostic biomarker of non-small cell lung cancer (1). PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins (2). PPM1H is also suggested to be a gatekeeper to prevent excessive bone morphogenetic protein (BMP) signalling through dephosphorylation (3).

Specifications

Detects ~55kDa

Product Name Alternative

Protein phosphatase Mg2+/Mn2+ dependent 1H Antibody | NERPP2C | Protein phosphatase 1H Antibody

Synonyms

PPM1H Antibody, Clone 10D2

UNSPSC

12352203

Gene ID

57460

Swiss Prot

Q9ULR3

Accession Number

NP_065751.1

Cellular Locus

Intracellular

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant Human PPM1H Protein

Target

PPM1H

Clonality

Monoclonal

Isotype

IgG1

Clone

10D2

Conjugation

Unconjugated

Tissue Specificity

Parathyroid gland

Validated Applications

WB,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-616 was sufficient for detection of PPM1H in 10 µg of Hu, Ms, Rt Kidney Cells (HEK293), Alveolar Basal Epithelial cells (A549) by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhang W.Q., et al. (2021) Neoplasma. 68(5): 917-923. 2. Berndsen K., et al. (2019) 8:e50416. 3.Shen T., et al. (2014) Cell Res. 24(6): 727-741.

Product Datasheet

https://cdn.gentaur.com/products/400/11821728/datasheet/smc-616s.pdf

Product MSDS

https://cdn.gentaur.com/products/400/11821728/msds/smc-616s.pdf

CAS Number

9007-83-4

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