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PPM1H Antibody: ATTO 488

Human Anti-Human PPM1H Monoclonal IgG1

Product Specifications

Background

PPM1H is an independent prognostic biomarker of non-small cell lung cancer (1). PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins (2). PPM1H is also suggested to be a gatekeeper to prevent excessive bone morphogenetic protein (BMP) signalling through dephosphorylation (3).

Specifications

Detects ~55kDa

Product Name Alternative

Protein phosphatase Mg2+/Mn2+ dependent 1H Antibody | NERPP2C | Protein phosphatase 1H Antibody

Synonyms

PPM1H Antibody, Clone 10D2: ATTO 488

UNSPSC

12352203

Gene ID

57460

Swiss Prot

Q9ULR3

Accession Number

NP_065751.1

Cellular Locus

Intracellular

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant Human PPM1H Protein

Target

PPM1H

Clonality

Monoclonal

Isotype

IgG1

Clone

10D2

Conjugation

ATTO 488

Tissue Specificity

Parathyroid gland

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-616 was sufficient for detection of PPM1H in 10 µg of Hu, Ms, Rt Kidney Cells (HEK293), Alveolar Basal Epithelial cells (A549) by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhang W.Q., et al. (2021) Neoplasma. 68(5): 917-923. 2. Berndsen K., et al. (2019) 8:e50416. 3.Shen T., et al. (2014) Cell Res. 24(6): 727-741.

Product Datasheet

https://cdn.gentaur.com/products/400/11821719/datasheet/smc-616d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/11821719/msds/smc-616d-a488.pdf

CAS Number

9007-83-4

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