RAB1A, Clone 4G10

Mouse Anti-Human RAB1A Monoclonal IgG1

Product Specifications

Background

RAB1A is a small GTPase localized to the membranes of the endoplasmic reticulum (ER) and Golgi apparatus. It regulates vesicular trafficking between these compartments and is essential for maintaining cellular homeostasis. In the nervous system, RAB1A supports the transport of proteins critical for synaptic function and neuronal survival. It has been implicated in the regulation of growth hormone secretion and intracellular signaling pathways. Dysfunction of RAB1A-mediated trafficking contributes to ER stress and impaired proteostasis—key features of neurodegenerative diseases such as Parkinson’s and Alzheimer’s. As a regulator of early secretory pathways, RAB1A is a potential target for modulating protein misfolding and aggregation in neurodegeneration.

CAS Number

9007-83-4

Specifications

Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.

Product Name Alternative

GTP binding protein RAB 1A, RAB 1, Rab 1A, Rab1A, RAB1A member RAS oncogene family, RAB1A_HUMAN, Ras related protein Rab 1A, Ras-related protein Rab-1A, YPT1-related protein, RAB1

Synonyms

RAB1A, Clone 4G10

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

5861

Swiss Prot

P62820

Accession Number

NP_004152.1

Cellular Locus

Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

Full length recombinant Human RAB1A protein

Target

RAB1A

Clonality

Monoclonal

Isotype

IgG1

Clone

4G10

Conjugation

Unconjugated

Tissue Specificity

Low tissue specificity.

Type

Monoclonal

Applications

WB | IP

Validated Applications

WB,IP

Field of Research

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-613 was sufficient for detection of RAB1A in 10 ug (A549, MEF) ; 20 ug (Mouse Brain) lysates by ECL immunoblot analysis.

Concentration

1mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Yang, X. et al. (2016) Oncogene. 35(44):5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.

Background Reference 01

1. Yang, X. et al. (2016) Oncogene. 35 (44) :5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820

Species

Human | Mouse

Location

Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane

Isotype

IgG1

Immunogen Species

Human

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