AS8351
AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells[1].
Product Specifications
CAS Number
[796-42-9]
Product Name Alternative
NSC51355
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/AS8351.html
Purity
99.88
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC=NC=C1)N/N=C/C2=C3C=CC=CC3=CC=C2O
Molecular Formula
C17H13N3O2
Molecular Weight
291.30
Precautions
H315, H319, H335
References & Citations
[1]Liu K, et al. Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine. Cell Chem Biol. 2016 Aug 18;23 (8) :893-916.|[2]Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016 Jun 3;352 (6290) :1216-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5
Available Sizes
Curated Selection
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