Danegaptide Hydrochloride

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].

Product Specifications

CAS Number

[943133-81-1]

Product Name Alternative

GAP-134 (Hydrochloride) ; ZP 1609 Hydrochloride

UNSPSC

12352005

Hazard Statement

H302

Target

Gap Junction Protein

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GAP-134-Hydrochloride.html

Concentration

10mM

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2.[H]Cl

Molecular Formula

C14H18ClN3O4

Molecular Weight

327.76

Precautions

H302

References & Citations

[1]John A Butera, et al. Discovery of (2S,4R) -1- (2-aminoacetyl) -4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134) 13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52 (4) :908-11.|[2]Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163 (3) :469-83.