PARL-IN-2
Product Specifications
UNSPSC Description
PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC50 value of 0.16 μM. PARL-IN-2 leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-2 promotes PINK1/Parkin-dependent mitophagy[1].
Target Antigen
Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy;Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/parl-in-2.html
Smiles
O=C(OCC1=CC=CC=C1)C2=CC=C(CN3C(C(CC)(CC)C3=O)=O)C=C2
Molecular Weight
365.42
References & Citations
[1]Ji S, Bach K, et al. 4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169380/PARL-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169380/
Clinical Information
No Development Reported
Curated Selection
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