(E) -10-Hydroxynortriptyline

(E) -10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417) . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A) [1]. E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.

Product Specifications

CAS Number

[47132-16-1]

Product Name Alternative

E-10-OH-NT

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-10-hydroxynortriptyline.html

Purity

99.65

Solubility

H2O : 3.57 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : ≥ 25 mg/mL

Smiles

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC

Molecular Formula

C19H21NO

Molecular Weight

279.38

Precautions

H302

References & Citations

[1]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22 (4) :371-8.|[2]Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.|[3]Bertilsson L, Nordin C, Otani K, et al. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clin Pharmacol Ther. 1986;40 (3) :261-267. |[4]Dumont E, von Bahr C, Perry TL Jr, Bertilsson L. Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes. Pharmacol Toxicol. 1987;61 (5) :335-341.