Diethyl succinate

Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings[1][2].

Product Specifications

CAS Number

[123-25-1]

Product Name Alternative

Diethyl Butanedioate

UNSPSC

12352211

Hazard Statement

H319, H402

Target

Biochemical Assay Reagents; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diethyl-succinate.html

Purity

99.99

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(OCC)CCC(OCC)=O

Molecular Formula

C8H14O4

Molecular Weight

174.19

Precautions

H319, H402

References & Citations

[1]Zacharias NM, et al. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1- (13) C diethyl succinate. J Am Chem Soc. 2012 Jan 18;134 (2) :934-43.|[2]Lixiang Wang, et al. "Diethyl succinate modulates microglial polarization and activation by reducing mitochondrial fission and cellular ROS." Metabolites 11.12 (2021) : 854.