Bromocriptine (mesylate)

Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

Product Specifications

CAS Number

[22260-51-1]

Product Name Alternative

CB-154

UNSPSC

12352005

Hazard Statement

H400, H410

Target

Autophagy; Dopamine Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Bromocriptine-mesylate.html

Purity

99.98

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : 1.1 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

[H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43.OS(=O)(C)=O

Molecular Formula

C33H44BrN5O8S

Molecular Weight

750.70

Precautions

H400, H410

References & Citations

[1]Gardner B, et al. Agonist action at D2 (long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124 (5) :978-84.|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406 (1-2) :33-6.|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25 (10) :1211-4.|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35 (1) :90-7.|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.