IL6ST Recombinant Protein
Product Specifications
Gene Name
Interleukin 6 signal transducer
Gene Aliases
5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699; D13Ertd699e; gp13; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; IL-6R-beta; interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha.
Gene ID
16195
Accession Number
NP_034690.3
Reactivity
Mouse|Mus musculus
Target
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649) . Has a role in embryonic development (PubMed:10661409) . Does not bind IL6 (By similarity) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352) . Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504) . Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
34kDa
Protein Length
Recombinant
NCBI Gene Symbol
Il6st
Host or Source
E.coli
Protein Name
Interleukin-6 receptor subunit beta
Gene Name URL
Il6st
CAS Number
9000-83-3
Nucleotide Accession Number
NM_010560.3
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