8-Hydroxyquinoline

8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice[1][2][3][4][5].

Product Specifications

CAS Number

[148-24-3]

Product Name Alternative

8-Quinolinol

UNSPSC

12352005

Hazard Statement

H301, H317, H318, H360, H410

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-Hydroxyquinoline.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C2N=CC=CC2=CC=C1

Molecular Formula

C9H7NO

Molecular Weight

145.16

Precautions

H301, H317, H318, H360, H410

References & Citations

[1]Lawung R, et.al. Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae. EXCLI J. 2018 Aug 23;17:840-846. |[2]8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells. J Biol Inorg Chem. 2010 Feb;15 (2) :259-69. |[3]Zhai S, et.al. Tumor cellular proteasome inhibition and growth suppression by |[4]Hamoud MA, et.al. Effects of quinoline and 8-hydroxyquinoline on mouse bone marrow erythrocytes as measured by the micronucleus assay. Teratog Carcinog Mutagen. 1989;9 (2) :111-8. |[5]Searle CE. The selective depigmenting action of 8-hydroxyquinoline on hair growth in the mouse. Br J Dermatol. 1972 May;86 (5) :472-80.