SART1 antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
U4/U6.U5 tri-snRNP-associated protein 1
Gene Aliases
HAF, Ara1, HOMS1, Snu66, SART1259, SNRNP110
Gene ID
9092
Accession Number
NP_005137.1
Reactivity
Human
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human SART1. The exact sequence is proprietary.
Target
This gene encodes two proteins, the SART1 (800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1 (259) protein expressed in the cytosol of epithelial cancers. The SART1 (259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1 (259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1 (259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1 (259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB
Purification
Purified by antigen-affinity chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Mouse, Rat, Zebrafish, Bovine, Xenopus laevis (>80% identity)
Format
Liquid.// 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) . 0.01% Thimerosal was added as a preservative.
Reconstitution
Keep as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4º° C. For long-term storage, aliquot and store at -20° C or below. Avoid multiple freeze-thaw cycles.
Molecular Weight
90 kDa
Fragment
IgG
NCBI Gene Symbol
SART1
Host or Source
Rabbit
Protein Name
U4/U6.U5 tri-snRNP-associated protein 1
Gene Name URL
SART1
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