HSD17B12 Antibody
Product Specifications
Gene Name
Hydroxysteroid (17-beta) dehydrogenase 12
Gene Aliases
17-beta-HSD 12;17-beta-hydroxysteroid dehydrogenase 12;2610510O05Rik;3-ketoacyl-CoA reductase; AI172963; estradiol 17-beta-dehydrogenase 12; KAR; keratoadhesin; keratonectin; KIK; Kik1; KIK-I; steroid dehydrogenase; very-long-chain 3-oxoacyl-CoA reductase.
Gene ID
56348
Accession Number
NP_062631.1
Reactivity
Mouse
Immunogen
Recombinant HSD17b12 (Met1~Asn312) expressed in E.coli
Target
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Source
Polyclonal antibody preparation
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
20 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against HSD17b12. It has been selected for its ability to recognize HSD17b12 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Hsd17b12
Host or Source
Rabbit
Protein Name
Very-long-chain 3-oxoacyl-CoA reductase
Gene Name URL
Hsd17b12
CAS Number
9007-83-4
Nucleotide Accession Number
NM_019657
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