SET2

SET2 is a selective TRPV2 antagonist (IC50=0.46 μM) . SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator) -induced cytoplasmic calcium increases[1].

Product Specifications

CAS Number

[2313525-20-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/set2.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(CCSC1=NC(C(F)(F)F)=CC(N(CCC)C)=N1)NCC2=CC=CO2

Molecular Formula

C17H21F3N4O2S

Molecular Weight

402.43

Precautions

H302, H315, H319

References & Citations

[1]Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62 (3) :1373-1384.