CAVEOLIN-3

Product Specifications

Gene Name

Caveolin 3

Gene Aliases

LQT9, MPDT, RMD2, VIP21, LGMD1C, VIP-21

Gene ID

859

Swiss Prot

P56539

Accession Number

NP_001225

Reactivity

Human, Mouse, Rat, Cow, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human CAV3

Target

CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD) . Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

Partner Proteins

KCNMA1; PTGES3; SCN5A; PCBP1; NEDD4L; KCNH2; SUMO2; SUMO3; ADRB2; JPH2; SLC22A11; DYSF; PFKM; SLC8A1; NOS1; INSR; GNAS; EGFR; DAG1; PDGFRB; PDGFRA

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVG

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Human: 100%; Mouse: 84%; Pig: 92%; Rat: 84%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

17kDa

Protein Length

151

NCBI Gene Symbol

CAV3

Host or Source

Rabbit

Protein Name

Caveolin-3

Gene Name URL

CAV3

Nucleotide Accession Number

NM_001234

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