IOWH-032

IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 μM. IOWH-032 also is a anti-diarrheal agent[1][2].

Product Specifications

CAS Number

[1191252-49-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CFTR; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/IOWH-032.html

Purity

99.63

Solubility

DMSO : ≥ 100 mg/mL

Smiles

BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1

Molecular Formula

C22H15Br2N3O4

Molecular Weight

545.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For  Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation|[2]de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3 (10) :1317-25.|[3]Lotti V, et al. CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells. Cells. 2022 Apr 15;11 (8) :1347.|[4]Thiagarajah JR, et al. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep;92 (3) :287-90.