Selitrectinib

Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and TRKA and TRKC, respectively[1].

Product Specifications

CAS Number

[2097002-61-2]

Product Name Alternative

LOXO-195

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LOXO-195.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

FC1=CN=C(CC[C@H](N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1

Molecular Formula

C20H21FN6O

Molecular Weight

380.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Drilon A, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discov. 2017 Sep;7 (9) :963-972.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

TrkA; TrkC

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

HY-166299 1 Each

C110-dolichol

Ask

View Details

E47R3357 100 µL

PYK2 Rabbit pAb

Ask

View Details

MBS8111968-01 0.02 mL

Recombinant Anti-CD6 Antibody, Rabbit Monoclonal

Ask

View Details

MBS8111968-02 0.1 mL

Recombinant Anti-CD6 Antibody, Rabbit Monoclonal

Ask

View Details

MBS8111968-03 5x 0.1 mL

Recombinant Anti-CD6 Antibody, Rabbit Monoclonal

Ask

View Details

Z01LS-0722-LS619 5 Plates

Human GAD65 Matched Antibody Pair Set [Z01LS-0722-LS619]

Ask

View Details