3,6-Dihydroxyflavone
Product Specifications
UNSPSC Description
3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP). 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation[1].
Target Antigen
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-6-dihydroxyflavone.html
Purity
99.45
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13
Molecular Weight
254.241
References & Citations
[1]Chang H, et al. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol. 2010;648(1-3):31-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N8481/3-6-Dihydroxyflavone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N8481/3-6-Dihydroxyflavone-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
108238-41-1
Available Sizes
Curated Selection
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