3,6-Dihydroxyflavone

3,6-Dihydroxyflavone is an anti-cancer agent. 3,6-Dihydroxyflavone dose- and time-dependently decreases cell viability and induces apoptosis by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP) . 3,6-Dihydroxyflavone increases intracellular oxidative stress and lipid peroxidation[1].

Product Specifications

CAS Number

[108238-41-1]

Product Name Alternative

3,6-DHF

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-6-dihydroxyflavone.html

Purity

99.45

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]Chang H, et al. 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. Eur J Pharmacol. 2010;648 (1-3) :31-38.