Rosmanol
Product Specifications
CAS Number
80225-53-2
Target
Antioxidant|||COX
Related Pathways
Neuroscience|||Oxidation-Reduction|||Immunology/Inflammation
Purity
0.9979
Bioactivity
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Smiles
[H][C@]12OC(=O)[C@@]3(CCCC(C)(C)[C@]13[H])c1c(O)c(O)c(cc1[C@@H]2O)C(C)C
Molecular Formula
C20H26O5
Molecular Weight
346.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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